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Written and directed by Coralie Fargeat (Revenge), The Substance stars Demi Moore (G.I. Jane, A Few Good Men, Indecent Proposal), Margaret Qualley (Once Upon a Time in Hollywood, Maid, Kinds of Kindness, Fosse Verdon), and Dennis Quaid (Far from Heaven, The Rookie, The Day After Tomorrow).

Director of Photography on the film is Benjamin Kracun (Promising Young Woman, Beast), co-editors are Coralie Fargeat, Jerome Eltabet (Revenge) and Valentin Féron, music is composed by Raffertie (I May Destroy You), Production Design is led by Stanislas Reydellet (Le Bal Des Folles), and Costume Design is by Emmanuelle Youchnovski (Café de Flore, La belle époque). 

The Substance, which is produced by Coralie Fargeat, and Eric Fellner and Tim Bevan for Working Title, comes after Fargeat’s acclaimed debut feature Revenge, which world premiered at the Toronto International Film Festival in 2017 and was written, directed and co-edited by Fargeat. Alexandra Loewy of Working Title and Nicolas Royer of A Good Story are Executive Producers.